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This poor efficiency was often due to technical difficulties associated with the extraction of viable tumor cells from their surrounding stroma. Surgery is generally considered safe during pregnancy, but some other treatments, especially certain chemotherapy drugs given during the first trimesterincrease the risk of birth defects and pregnancy loss spontaneous abortions and stillbirths. During the s, a new understanding of metastasis led to perceiving cancer as a systemic illness as well as a localized one, and more sparing procedures were developed that proved equally effective. Staging takes into consideration size, local involvement, lymph node status and whether metastatic disease is present. They attach to other cells and stay in place in tissues. Effusions provided generally large numbers of dissociated, viable tumor cells with little or no contamination by fibroblasts and other tumor stroma cells.

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The dominant values are selflessness, cheerfulness, unity, and optimism.

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Therapeutic genetic correction strategies". Biochimica et Biophysica Acta. Breast cancer Mammograms showing a normal breast left and a breast with cancer right, white arrows. Most types of breast cancer are easy to diagnose by microscopic analysis of a sample—or biopsy —of the affected area of the breast. Retrieved 9 October

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