Capsule Thus, our results provided the first epidemiological evidence supporting the involvement of TDRD1 genetic polymorphisms in piRNA processing genes in determining the risk of spermatogenic impairment in a Han Chinese population. The Tex11 gene is conserved in vertebrates and encodes a kDa protein with a tetratricopeptide repeat motif that mediates protein-protein interactions [ 1112 ]. Impairment of spermatogenesis leading to infertility. Thus, variations in piRNA pathway genes may play a role in spermatogenic impairment. Surprisingly, the same exonic missense mutation WC was observed in two brothers but not in their mother. In particular, proteins encoded by Piwi genes are essential for the biogenesis and function of piRNAs [ 1314 ]. Send to a friend Print this page.
In the present study, we identified one novel exonic missense TEX11 mutation WC in two brothers but not their mother.
What Does it Take to Become a Sperm Donor?
Therefore, we speculated that these SNPs might have special functions in the Chinese population. The only necessities are that you should not have any history of sexually-transmitted infection, or a personal or family history of inheritable disorders. Fluorescence in situ hybridisation analysis of sex chromosome in non-obstructive azoospermic men. He said he chose to be an open ID donor so any future children will be able to contact him once they turn Trinucleotide CAG repeat polymorphisms in the androgen receptor gene: